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National Heart, Lung, and Blood Institute Stops Trial of Estrogen Plus Progestin Due to Increased Breast Cancer Risk, Lack of Overall Benefit

As report nationwide on the July 10th, 2002. The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) has stopped early a major clinical trial of the risks and benefits of combined estrogen and progestin in healthy menopausal women due to an increased risk of invasive breast cancer. The study had planed to run though 2005.

The study included 16,608 women age 50 to 79 its findings for the estrogen plus progestin group compared to placebo include:

A 41 percent increase in strokes
A 29 percent increase in heart attacks
A doubling of rates of venous thromboembolism (blood clots)
A 22 percent increase in total cardiovascular disease
A 26 percent increase in breast cancer
A 37 percent reduction in cases of colorectal cancer
A one-third reduction in hip fracture rates
A 24 percent reduction in total fractures
No difference in total mortality (of all causes)

According to Jacques Rossouw, M.D., acting director of the WHI, the adverse effects of estrogen plus progestin applied to all women, irrespective of age, ethnicity, or prior disease status.

Read the complete news release.

The news media acts if this news is brand new. Ann Louis Gittleman, M.S., C.NS. states in her book "Hormone replace therapy may appear to be teh easy way out. If it were, believe me, I would be telling you so in the large type. But synthetic hormone replacement therapy has side effects, some of which are extremely dangerous. And the longer you stay on any drug therapy, the greater the chance of side effects" first published in 1998.
Mrs. Gittleman also lists possible side effects of HRT as Blood Colts, Breast Cancer. Both of which were the reason the HRT study was stopped. The book has a indepth explainations about Premarin and Provera.

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